【Abstract】 Antiangiogenic therapy is a hot topic in the field of cancer treatment, through the inhibition of tumor angiogenesis can achieve the internal of "starve the tumor". With the further research of anti angiogenesis therapy for tumor, some scholars pointed out that the structure and the function of the tumor microvasculature may have a trend to normalization time in the effect of anti angiogenesis drugs, namely the vascular normalization window. Results show that antiangiogenic therapy combined with chemoradiotherapy in the time window will improve antitumor efficacy. Recombinant human endostatinEndostaris a new anti angiogenic drugs, which Chinese have a completely independent intellectual property rights.Determined the time window of Endostar is of great significance to guide the antitumor treatment of Endostar. The following will review the study of Endostar’s time window.