【Abstract】Objective To investigate the influence of comprehensive nursing intervention on anxiety, depression and selfperceiving of patients with percutaneous coronary intervention. Methods 100 patinets with CHD in our hospital from January 2013 to January 2015 were selected and divided into control group and observation group. They were given SAS, SDS and SCL-90 PCI. The control group was given common nursing. The observation group was given comprehensive nursing intervention based on the methods of control group. After surgery, the psychological tests were given to patients. Results SAS, SDS and SCL-90 of two groups before intervention were large than threshold value (P>0.05). After different intervention, SAS, SDS and SCL-90 of observation group were higher than that of control group. SAS, SDS and SCL-90 of control group were higher than that before intervention. SAS, SDS and SCL-90 of control group after intervention were higher than that of observation group (P<0.05). Conclusion CHD patients after PCI may exist anxiety and depression. Comprehensive nursing intervention can improve condition of patients and is worthy of wide application and promotion