【Abstract】Objective To explore the detection value of serum uric acid level in bipolar disorder, including the value of biomarkers and the value of the status marker. Methods Between May 2013 and February 2016, 322 patients with bipolar affective disorder were selected in our hospital, according to the individual patient medical records and the Young Mania Rating Scale, Hamilton depression scale. 197 cases of patients with manic episode were included in the manic group. 125 patients with depressive episode were included in the depression group. At the same time according to the patient psychiatric drug situation, 241 patients were included in the untreated group, 81 patients were included in the medication group. In the same period, 77 patients with first episode schizophrenia selected in our hospital were included in the schizophrenic group. 322 cases of healthy adults for health examination in our hospital were included in the healthy control group. The correlation between serum uric acid level and the symptoms of bipolar disorder was observed and compared between the groups. Results The serum uric acid level in the treatment group (37414 ± 10475μmol/L) was slightly higher than the untreated group (33942 ± 10715μmol/L )(P>0.05). The serum uric acid level in the observation group (34944±10621μmol/L) was evidently higher than that of the schizophrenic group (31881±8558μmol/L) (P＜0.05). The serum uric acid levels in the observation group and the schizophrenia group were evidently higher than those in the control group (P＜0.05). Manic group of serum uric acid (365.54±10311μmol/L) was evidently higher than that of depression group (321.45±107.68μmol/L) (P＜0.05). Manic group and depression group patients serum uric acid levels were evidently higher than the control group (P＜0.05). Bipolar affective disorder manic group of Young Mania Rating Scale scored between 21 to 50, with a median of 36 (31, 39), serum uric acid level and mania of the correlation coefficient was r=0.09 ( P>0.05). Bipolar affective disorder patients with depressive Hamilton Depression table scored in 17 to 45, with a median of 32 (23, 38), serum uric acid levels and depressive episode of the correlation coefficient was r=0.26 ( P>0.05). Conclusion The clinical doctor can examine the serum uric acid level as the initial screening of the patients with bipolar disorder, but not the level of serum uric acid level as the indicator of the severity of the bidirectional affective disorder.