【Abstract】Objective To analyze the clinical efficacy of precise hepatectomy and irregular hepatectomy in the treatment of intrahepatic bile duct stones and provide the theoretical basis for clinical treatment. Methods 96 patients with intrahepatic bile duct stones were selected as subjects admitted to our hospital from October 2014 to August 2016. Patients were divided into observation group and control group (48 cases in each group) according to different treatment methods. The patients in the observation group were treated with precise hepatectomy, and the patients in the control group were treated with irregular hepatectomy. The stone clearance rate, operation time, intraoperative blood loss, hospital stays, hospitalization expenses, postoperative complications and liver function indexes (ALT, TBIL, TBA, ALP, GGT) changes of the two groups were observed. Results The hospitalization time, treatment costs, the amount of intraoperative bleeding in the observation group were less than that of the control group (P＜0.05). The surgical treatment time of observation group was longer than that of the control group (P＜0.05). The proportion of Kangfuyou in the observation group (7500%) was significantly higher than that in the control group (47.92%)(P＜0.05). The proportion of benign (2083%) was significantly lower than that of control group (45.83%) (P＜0.05). No difference was detected between the two groups (P>0.05). The clinical curative effect of the observation group was better than that of the control group (P＜005). The removal rate of stones in the observation group was ［93.75% (45/48)］and the control group was ［6667% (32/48)］. The removal rate of stones in the observation group was significantly higher than that in the control group (χ2=11.090, P=0.001). ALT, TBIL, TBA, ALP, GGT were not significantly different between the two groups before treatment (P>0.05). ALT, TBIL, TBA, ALP and GGT were improved in the two groups after treatment,but the improvement of the observation group was significantly better than that of the control group (P＜0.05). The incidence of complications in the observation group (12.50%) was significantly lower than that in the control group (31.25%) (P＜0.05). Conclusion Intrahepatic choledocholithiasis is treated with precise hepatectomy and irregular liver resection. The operation time is longer than the irregular liver resection. The clinical treatment, liver function improvement, stone clearance rate and the complications and other aspects of the observation group are better than that of the control group. It can reduce the length of hospital stay and hospitalization costs.