【Abstract】Objective To evaluate the clinical efficacy of pantoprazole, domperidone and hydrotalcite triple therapy on chronic gastritis patients.Methods 126 patients with chronic gastritis disease from July 2013 to July 2015 in our hospital were randomly divided into the observation group (63 cases) and the control group (63 cases). The observation group was treated with pantoprazole, domperidone, hydrotalcite triple treatment. The control group was treated with pantoprazole and aluminum magnesium carbonate treatment. The treatment effect, adverse reaction and symptom remission time were observed.Results The effective rate and total effective rate of the observation group were 57.14% (36/63) and 95.24% (60/63), respectively, which were significantly higher than that of control group (36.51% and 80.95%). The symptom disappearance rate in the observation group was significantly higher than that of the control group (P＜0.05). The epigastric pain, epigastric discomfort, dizziness, nausea and vomiting, abdominal distention, belching and other adverse reaction disease patient ratio in the observation group were significantly lower than that of the control group (P＜0.05). T The burning acid reflux, retrosternal pain and feeling of pharynx ministry eyewinker symptoms slow solution or disappearance time of observation group were significantly lower than those of the control group (P＜0.05). Conclusion Pantoprazole, domperidone, hydrotalcite triple therapy on chronic gastritis disease has a very significant therapeutic effect. It can effectively alleviate the clinical symptoms and reduce the disappearance time of symptoms.