【Abstract】Objective To investigate the clinical efficacy of combined use of sodium nitroprusside and dopamine in the treatment of refractory heart failure.Methods From June 2014 to July 2016, 92 patients with refractory heart failure were randomly divided into the observation group and the control group with 46 cases in each group. The control group was given routine treatment, while the observation group was additionally treated with sodium nitroprusside and dopamine. The total effective rate was compared between the groups. The heart rate (HR), mean arterial pressure (MAP), respiratory rate,left ventricular ejection fraction (LVEF), cardiothoracic ratio (CTR) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were used to evaluate the cardiac function. The 6min walk test (6MWT), serum creatinine (Scr), blood urea nitrogen (BUN) and blood uric acid (UA) were compared between groups, and the adverse reactions were observed. Results The effective rate of treatment in the observation group (95.65%) was significantly higher than that in the control group (80.43%) (P<0.05). After treatment, HR, MAP and respiratory rate in the observation group were lower than those in the control group (P<0.05). After treatment, LVEF of the observation group was higher than that of the control group, while CTR and NT-proBNP level, were lower than those in control group (P<0.05). After treatment, 6MWT of the observation group was longer than that of the control group, while Scr, BUN and UA levels were significantly lower (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Treatment of refractory heart failure with sodium nitroprusside combined with dopamine can improve the heart and kidney function and related laboratory routine indexes, with good clinical curative effect and little adverse reaction.