高血压脑出血术后48小时强化降压对预后的影响
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新疆维吾尔族自治区高血压病研究所重点实验室开放课题(XJYS0906-2014-03)


Intensive blood control on the outcomes for postoperative hypertensive cerebral hemorrhage patients within 48 hours: a randomized controlled trial
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    摘要:

    【摘要】目的 对比高血压脑出血术后强化降压与常规降压的安全性与有效性。方法 采用随机对照临床试验方法, 纳入2014年5月至2016年1月收治的高血压脑出血术后患者的临床资料。随机分为常规治疗组(收缩压控制在160-140mmHg)和强化治疗组(收缩压控制在140-120mmHg),并对两组治疗结果进行比较。结果 共有111例患者完成试验, 其中常规治疗组57例, 强化治疗组54例, 常规治疗组和强化治疗组术后48h的血肿体积变化和再出血率无显著差异(P>0.05)。两组患者术后48h和术后3个月的GCS、NIHSS、改良MRS评分均无显著差异(各P>0.05)。结论 对于高血压脑出血术后患者, 采用标准降压和强化降压均是安全的, 两组疗法的近期效果和长期预后相似。

    Abstract:

    【Abstract】Objective The aim of the study was to evaluate the safety and efficacy of early intensive and conservative BP lowering treatment in patients with hypertension cerebral hemorrhage. Methods By randomized controlled clinical trial, the clinical data of patients with hypertension cerebral hemorrhage treated from May 2014 to January 2016 were collected. The patients were randomly divided into conventional treatment group (systolic pressure control 160140mmHg) and intensive treatment group (systolic pressure control in 140120mmHg).Results 111 patients completed the trial, including the conventional treatment group (57 cases) and intensive treatment group (54 cases). There was no significant difference in the volume of hematoma (21±29 vs 29±25 ml, P=0.351) and rebleeding rate (15.8% vs 5.6%, P=0.604) in the conventional treatment group and the intensive group 48h after operation. GCS of the two groups of patients with postoperative 48h and postoperative 3 months (8.53±3.08 vs 8.00±3.27, P=0.617 and 13.05±1.99 vs 11.44±3.88, P=0.119), NIHSS (24.58±8.35 vs 23.61±9.91, P=0.749 and 7.53±5.97 vs 10.44±8.40, P=0.229), modified MRS score (4.63±0.60 vs 4.67±0.77, P=0.877 and 2.53±1.47 vs 2.89±1.61, P=0.478) had no significant difference. Conclusion For patients with hypertension cerebral hemorrhage after surgery, the use of standard antihypertensive and enhanced blood pressure are safe, the two groups of shortterm prognosis and longterm prognosis are similar.

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  • 在线发布日期: 2017-12-18
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