【Abstract】Objective To systematically review the clinical efficacy of Levosimendan to treat patients with acute right heart failure. Methods We searched through foreign (Pubmed, Medline, Springer, etc) and domestic (CNKI, wanfang, etc) databases with the purpose of collecting related research papers about clinical efficacy of Levosimendan to treat patients with acute right heart failure. Valid data were analyzed with Meta-analysis using the Software RevMan 5.2 and drew forest plot. Choosing Standardized mean difference (SMD) was the effect quantity of measurement data. Results 11 trials and 439 patients were included. Results of Meta-analysis showed that the difference of tricuspid annular plane systolic excursion(TAPSE), systolic pulmonary artery pressure(sPAP), ejection fraction(EF) and pulmonary vascular resistance(PVR) between the two groups had statistical significance. SMD value and 95%CI were 1.53 (0.54, 2.53)，-6.15(-9.29, -3.02)，3.59(1.21, 5.98) and -39.48 (-65.59, -13.38), respectively. Conclusion The clinical efficacy of Levosimendan to treat patients with acute right heart failure is significant. However, the present study included a relatively small number of patients, and the long-term effects of Levosimendan remain unclear, more high-quality controlled trials are required.