【Abstract】Objective To investigate the clinicpathologic features of adenocarcinoms in situ of the cervical and minimal deviation adenocarcinoma. Methods 1 case of adenocarcinoms in situ of the cervical and minimal deviation adenocarcinoma was collected and analyzed with review of related literature. Immunohistochemical staining was performed to detect CEA, P53, Ki67, P16, Calponin using the SP method. Results The main symptoms included the watery discharge of cervix, with or without the biopsy difficulty with diagnose after the technique. The part of the gland was highgrade intraepithelial neoplasia and adenocarcinoma in situ and minimal deviation adenocarcinoma. Tumors are mainly composed of mucinous glands that are welldifferentiated by invasive growth. Gland distribution was mostly dense, disorder and shape variable. Tumor cells had mild atypical hyperplasia. Immunohistochemical results included CEA (focal +), P53 (-), Ki67 index 5%, P16 (-), Calponin (smooth muscle +), SMA(smooth muscle +), ER(+), PR(-) and CA125 (-). Conclusion Minimal deviation adenocarcinoma is a rare well differentiated mucinous adenocarcinoma, high degree of differentiation and easy to misdiagnosis. The clinical manifestations, symptoms and signs, immunohistochemistry has a certain diagnostic value for diagnose of adenocarcinoms in situ of the cervical and minimal deviation adenocarcinoma.