【Abstract】 Peroxisome proliferatoractivated receptorγ belongs to type Ⅱ nuclear hormone receptor superfamily member,which plays a decisive role in regulation the differentiation direction of bone marrow stromal stem cells,induces the fat differentiation,and hold the osteogenetic differentiation.Glucocorticoids can obviously increase PAYγ gene expression in the rat,rabbit and human BMSCs,which causes a lot of fat accumulation in femoral head,medul lary cavity pressure increases,blood supply decrease and ischemia,Eventually induces steroidinduced avascular necrosis of the femoral head(SANFH).This paper reviews the research progress of PPARγ involved in the pathophysiology of SANFH pathogenesis.