【Abstract】 Objective To determine the associations of liver lobebased magnetic resonance diffusion weighted imaging (DWI) using multiple b values with cirrhosis in patients with hepatitis B. Methods Seventyfour cirrhotic patients with hepatitis B and 25 healthy volunteers underwent DWI with b values of 0, 500, 800 and 1000 sec/mm2. Apparent diffusion coefficients of individual liver lobes for b(0,500), b(0,800) or b(0,1000) were derived from the signal intensity averaged across images obtained with b values of 0 and 500 sec/mm2, of 0 and 800 sec/mm2, or of 0 and 1000 sec/mm2, respectively; and apparent diffusion coefficients (ADCs) of left lateral liver lobe (LLL), left medial liver lobe (LML), right liver lobe (RL) and caudate lobe (CL) for b(0,500), b(0,800) or b(0,1000) were statistically analyzed to evaluate cirrhosis. Results ADCs for b(0, 500), b(0, 800) and b(0, 1000) were inversely correlated with ChildPugh class in LLL, LML, RL and CL (r =035 to060, all P ＜005) except ADC for b(0,1000) in LML (r =017, P > 005). Among parameters, ADC for b(0, 500) in LLL could best differentiate normal liver from cirrhosis with an area under receiver operating characteristic curve (AUC) of 0989. Conclusion Liver lobebased apparent diffusion coefficients for b(0,500), b(0,800) tend to be associated with cirrhosis. Apparent diffusion coefficients for b(0,500) in LLL can best identify cirrhosis.