【Abstract】 Objective To explore the technique and clinical effect of hepatic vein approach in anatomical hepatectomy. Methods 117 patients undergoing anatomical hepatectomy through hepatic vein approach admitted to our Hospital from September 2014 to October 2016 were collected. Among the 117 cases, the method of crosssectional study was adopted. The method, duration, amount of bleeding,intraoperative blood transfusion,the recovery time of liver function and complications were observed. Results All the 117 patients were given the treatment of anatomical hepatectomy with Hepatic vein approach, The average operation time was 2396min(range,90600min). The average operation blood loss was 3174ml (range,503000ml), and 31 cases were given blood transfusion. The average recovery time of transaminase was 55days(310 days). There were 1 patients with hepatic failure,1 with peritoneal effusion .No case of bile leakage or intraabdominal bleeding. There was no patient died in perioperative period. The oneyear overall survival rate and diseasefree survival rate of 85 patients (HCC) were 98% and 93%. The twoyear overall survival rate and diseasefree survival rate were 81% and 52%.Conclusion Hepatic vein approach in anatomical hepatectomy is effective in reducing operation blood loss, reducing the probability of complications and precision hepatectomy. But the operator is needed in liver anatomy and ability of hepatic vein disposing further.