【Abstract】 Objective To investigate the Effects of perfluorocarbon on the inflammatory reaction induced by LPS and the expression of single immunoglobin IL1 receptor related protein (SIGIRR) in alveolar epithelial cells (A549 cells). Methods The A549 cells were divided into four groups (normal cell group, PFC+LPS group, PFC group and LPS group). A549 cells of each group were incubated for 24 h, and then the culture supernatants, cellular total protein and cellular nuclear protein were collected. The levels of TNFα, IL6 and IL10 in the culture supernatants were detected by ELISA. The protein expression levels of NFκB p65 in nuclear extracts and the protein expression levels of SIGIRR in A549 cells of each group were also measured by Westernblot analysis. Results The results of ELISA demonstrated that the levels of TNFα and IL6 in LPS group were higher than those in normal cell group (P＜005). Compared with LPS group, the levels of TNFα and IL6 in PFC+LPS group were significantly decreased (P＜005). Meanwhile, the results of ELISA also demonstrated that the levels of IL10 in PFC+LPS group were higher than those in LPS group and PFC could promote IL10 secretion in A549 cells (P＜005). The results of Westernblot analysis showed that the protein levels of phosphoNFκB p65 in LPS group were higher than those in normal cell group (P＜005). Compared with LPS group, the protein levels of phosphoNFκB p65 in PFC+LPS group were significantly decreased (P＜005). Moreover, the results of Westernblot analysis also showed that the protein levels of SIGIRR in PFC+LPS group were higher than those in LPS group and PFC could upregulate the expression of SIGIRR in A549 cells (P＜005), conversely, LPS suppressed the expression of SIGIRR in A549 cells. Conclusion PFC could attenuate the LPSinduced inflammation in alveolar epithelial cells. Promotion of IL10 secretion and upregulaiton SIGIRR expression may the possible mechanism of PFC protection against LPSinduce inflammation in alveolar epithelial cells.