【Abstract】 The survival of skin flap transplantation is one of the difficult problems in burn and plastic surgery, because it mainly subjected to ischemia reperfusion injury and vascular network constraints. That’s why it cannot further improve flap survival rate. The mechanism of ischemia reperfusion injury includes: oxygen free radicals and other active oxygen generation, neutrophil cell aggregation mediated inflammatory reaction, nitric oxide (No), calcium (Ca2+) overload and energy metabolism barrier, apoptosis and so onRecombinant human growth hormone in promoting protein synthesis, reduce the protein decomposition, immune regulation, promote wound healing and angiogenesis plays an important roleThis paper reviews the research progress of the effect of rhGH on the survival of the flap