【Abstract】 Objective To observe the effect of compressor atomization inhalation and oxygendriven inhalation method for elderly patients with AECOPD.Methods 96 elderly patients were randomly divided into group A and group B. Group A (compressor atomization inhalation) and group B (oxygen atomization inhalation) were treated with the same drug and the same doses. The arterial blood gas analysis, PEF detection and clinical symptoms by CAT were observed. Results After atomization treatment, clinical symptom score（CAT）were reduced in both group. The clinical symptom score of group B more obviously decreased than that of group A (P＜ 005). There was no significant difference between the two groups in PEF detection(P＞ 005). PH, PO2, SaO2 were increased and PCO2 were reduced in both groups(P＜ 005). PO2 and SaO2 increased in group B were more significant than that of in group A (P＜ 005). Conclusion Two kinds of atomization inhalation may adopt, but the oxygendriven atomizer is superior to air compressed atomizer in improving symptoms and oxygen displacement.