【Abstract】 Objective To evaluate the clinical value and method of percutaneous catheter drainage (PCD) for severe acute pancreatitis (SAP). Methods 15 patients with SAP were retrospectively analyzed. The mean draining time was 25.4 days after the onset of disease. Of 15 cases, 8 cases received B ultrasound guided PCD, 6 cases underwent CT guided PCD and 1 case was given CT and B ultrasound guided PCD at the same time. The 15 operations were all successful. The indwelling pigtail catheter was washed intermittently. The catheter was replaced for tube blockage or debridement with soft microscopy. Results All 15 patients were successfully drained. 13 patients were cured and 2 patients received surgical intervention again. The complications included pancreatic leakage (1 case) and intestinal fistula (2 cases). All were cured with conservative treatment. 1 patient died of MODS. Conclusion The image guided percutaneous puncture has little trauma and patients recover quickly. It can be the first choice to cure peripancreatic infection of SAP when we choose the appropriate puncture time, the correct puncture point and drainage method.