【Abstract】 Objective To investigate the effects of systematic nursing intervention on improving the quality of radionuclide myocardial perfusion imaging.Methods 398 patients with radionuclide myocardial perfusion imaging from January 2016 to January 2017 in our hospital were divided into control group (199 cases) and experimental group (199 cases), according to random number table. The control group was treated with routine care. The experimental group was treated with systematic nursing intervention. The incidence of adverse reactions and blood pressure change were observed.Results In the experimental group, there were 32 cases (16%) with blood pressure change, 29 cases (14.6%) with complexion change, 31 cases (15.6%) with respiratory frequency change, and 60 cases (30.2%) with adverse reaction. In the control group, there were cases 56 (28%) with blood pressure change, 49 cases (24.6%) with complexion change, 62 cases (31.2%) with respiratory frequency change, and 111 cases (55.8%) with adverse reaction. There were statistically significant differences between the two groups (P＜0.05).Conclusion Systematic nursing intervention can effectively reduce the incidence of adverse reaction and blood pressure change in patients with radionuclide myocardial perfusion imaging.