【Abstract】 Objective To explore the clinical effect of different anesthesia on radical operation of infant laparoscopic congenital megacolon. Methods 60 infants with congenital megacolon were randomly divided into into observation group (30 cases) and control group (30 cases). The control group was treated with tracheal intubation. The observation group was treated with general anesthesia combined with sacral block. The HR, SBP, DBP and PIP were recorded at T1 (before operation), T2 (5min after CO2 pneumoperitoneum), T3 (10min after CO2 pneumoperitoneum), T4 (10min after CO2 pneumoperitoneum ending) and T5 (5min after anal operation). The dose of fentanyl, propofol and vecuroniun was recorded. The incidence of postoperative complications and postoperative waking time were observed. Results The HR, SBP, DBP and PIP of T2, T3, T4 and T5 were significantly higher than T1 (P＜005), and the HR, SBP, DBP and PIP of observation group were significantly better than that of control group (P＜005). The dose of vecuronium of observation group［(8877±1024) μg/kg·h］ , fentanyl ［(287±623)μg/kg·h］ and propofol ［(533±070) mg/kg·h］ were significantly less than that of control group (P＜005). The postoperative revival time of observation group (1225±527)min was significantly shorter than that of the control group ［(1732±522)min P＜005］. The different degree of adverse reactions of observation group was significantly lower than that of the control group. (P＜005).Conclusion The clinical effect of infant laparoscopic radical operation of congenital megacolon is remarkable, which can effectively reduce the dosage of the narcotic analgesics and the incidence of postoperative adverse reactions.