【Abstract】 Objective To explore the differences of corneal curvature and radius determined with Pentacam and IOLMaster. Methods The corneal curvature and radius of 80 eyes of 40 subjects were determined with Pentacam and IOLMaster. Paired t test and Pearson correlation analysis were used to analyze the difference of keratometry (K) ［ K= (K1+K2)/2］and radius of curvature (R) ［R=(R1+R2)/2］ between the two methods. BlandAltman method was used to evaluate the agreement of the two methods. Results The K value of Pentacam and IOLMaster were 4356±168D and 4362±159D for (P＞005). The radius of curvature of Pentacam and IOLMaster were 776±005 mm and 774±005 mm (P＞005). Squared correlation coefficient was 09741 for Pentacam and 09573 for IOLMaster. The BlandAltmann showed that the two modalities had incomparable results for K values and the radius of curvature. Conclusion Pentacam and IOLMaster cannot be interchanged for keratometry and radius of curvature.