712例肾活检临床病理分析
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雅安市重点科技计划项目(S1430301)


Clinical pathological analysis of 712 cases of renal biopsy
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    【摘要】 目的 探讨肾脏病理类型分布及原发性肾小球疾病病理类型年龄段分布及其特点。方法 回顾性分析2010年1月~2016年9月712例在雅安市人民医院行肾活检患者肾脏病理类型分布和临床分型,分析几种原发性肾小球疾病病理类型年龄段分布的特点。结果 712例肾活检患者中,原发性肾小球疾病533例(7486%),常见的病理类型依次为IgA肾病224例(4203%)、微小病变肾病116例(2176%)、膜性肾病100例(1876%)、系膜增生性肾炎47例(882%)和局灶节段性肾炎29例(544%);继发性肾小球疾病173例(243%),以狼疮性肾炎最常见,其次为紫癜性肾炎及糖尿病肾脏疾病;肾小管间质疾病6例(084%)。原发性肾小球疾病临床类型依次为肾病综合征286例(5366%)、慢性肾炎204例(3827%)、隐匿性肾炎30例(563%)、急性肾炎11例(206%)、急进性肾炎2例(038%)。15岁以下患者原发性肾小球疾病病理类型以微小病变型最常见,16~45岁为IgA肾病的高发年龄,占总患者的7054%;31~60岁膜性肾病的高发年龄,占总患者的70%。结论 本院肾脏疾病以原发性肾小球疾病最常见,其中IgA肾病是最多见的病理类型。膜性肾病和微小病变肾病的检出率有增高趋势。其中,IgA肾病、微小病变肾病以及膜性肾病有着明显的年龄段分布特点。继发性肾小球疾病以狼疮性肾炎和紫癜性肾炎最常见。

    Abstract:

    【Abstract】 Objective To analyze the distribution characteristics of renal pathological type and the age distribution characteristics of different glomerular diseases in 712 cases of renal biopsy in Ya′an People′s Hospital during the past 6 years. Methods 712 cases of renal biopsy in Ya′an People′s Hospital from September 2016 to January 2010 were divided into 5 groups according to age. The pathological types of primary glomerular diseases based on age distribution were analyzed.Results Among the 712 patients,primary glomerulonephritis (PGN, 7486%)was the most frequent type, followed by secondary glomerulonephritis (SGN, 243%) and tubulointerstitial nephritis (TIN, 084%). Among PGN, IgA nephropathy was the most frequent pathology type, followed by minimal change disease (MCD), membranous nephropathy (MN), mesangial proliferative glomerulonephritis (MsPGN) and focal segmental glomerulosclerosis (FSGS). Lupus nephritis (LN) was the most common form of SGN, followed by henochschonlein purpura nephritis (HSPN) and diabetic kidney disease (DKD). There were 286 patients (5366%) with kidney disease nephrotic syndrome,204 patients (3827%)with chronic glomerulonephritis, 30 patients (563%) with latent glomerulonephritis,11 patients (206%) with acute nephritis and 2 patients (038%) with rapidly progressive glomerularnephritis in the clinical classification of 533 PGN patients. Of patients under 15 years old,the most frequent PGN was MCD. There was an agespecific impact on the constitution of histopathology types.70.54% patients of IgAN aged between 16~45 years old. 70% patients of MN aged were between 31~60 years old.Conclusion PGN is most common histological type in Ya′an People′s Hospital. IgAN is the most common types in PGN, and the incidences of MN and MCD have been increased. For SGN, LN and HSPN are the most frequent types.

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  • 在线发布日期: 2017-05-22
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