【Abstract】 Objective To study the sheath sheath in the clinical application of percutaneous nephroscope lithotripsy and practical value. Methods 118 patients with kidney stones were divided into experimental group (60 cases) and control group (58 cases). The experimental group was treated with sheath of sheath in percutaneous nephrolithotomy. The control group was treated with F20 single sheath in percutaneous nephrolithotomy. The operation time, stone clearance rate and complications were observed. Results There were 99 cases with once- lithotomy success and 5 cases with twice- lithotomy success. The calculus complete removal patients of experimental group and control group were 55 case (9166%) and 44 cases (7586%) (P＜005). The operation time of experimental group was short than that of control group (P＜005). The incidence of the two groups was not different (P＞005). Conclusion The sheath of sheath in percutaneous nephrolithotomy can shorten the operation time and improve the calculi clearance rate.