【Abstract】 Tuberculosis (TB) is one of the major public health problem in the world，which seriously threaten to human health and life safety. With the growing mobility of the population and using nonstandard of the antiTB drugs, the proportion of drugresistant tuberculosis (DRTB) increases year by year. Doctor face to the patients with DRTB is full of challenges, because of the complicated clinical manifestation and the light symptom. DRTB mainly relies on drug sensitivity test which brings great difficulty to clinical diagnosis. Once it becomes extensivelyresistant tuberculosis (XDRTB), clinical treatments will seem helpless. This article reviewed the progress in the study of DRTB in recent years.