【Abstract】 Objective To study the effect of Wechat platform on health education in patients with gynecological disease. Methods 148 patients with gynecological disease were randomly divided into control group and experimental group. The control group conducted routine nursing. Experimental group adopted health education by Wechat platform. Then we compared the differences of disease knowledge, anxietydepression status, life quality and patients satisfaction. Results After the implementing of Wechat platform, the score of disease knowledge was increased. SAS and SDS score were decreased, respectively. The score of life quality and patients satisfaction was improved. The differences were statistically significant (P＜005). Conclusion Wechat platform can increased the disease knowledge, improve anxietydepression status, life quality and patients satisfaction.