【Abstract】 Objective To find out the related factors that influence the effect of ultrasonic atomizing inhalation in children. Methods 120 children with respiratory diseases were divided into observation group and control group. The related factors affecting the effect were analyzed. Results The effect of children with seat atomizing treatment was better than that of lying position. The effect of respiratory frequency changed was not better than that un-changed. The effect of interval of treatment more than 4hours was better than that less than 4 hours. The effect of compliant children was better than that of Noncompliant children. Logistic regression analysis showed that body position, respiratory frequency, interval time and compliance were the influent factors of the effect. Conclusion Ultrasonic atomizing inhalation has the characteristics of high safety and rapid onset of action. It can improve the curative effect of the patients with the treatment of the body position, compliance and interval time.