【Abstract】 Objective To investigate the effects of shortsegment pedicle screw fixation for treating nonadjacent multisegmental spinal fractures. Methods 108 patients with nonadjacent multisegmental spinal fractures based on randomly were equally divided into the treatment group and the control group. The control group were given longsegment posterior pedicle screw fixation. The treatment group was given short segmental pedicle screw fixation. Results All patients were completed the treatment. The operative time and blood loss in the treatment group were significantly less than that of the control group (P＜005). The postoperative infection, back pain, cerebrospinal fluid leakage and other complications in the treatment group were significantly less than that in the control group (P＜005). The postoperative leading edge vertebral height ratio was significantly increased. Cobb angle was significantly reduced (P＜005). The postoperative leading eading edge vertebral height ratio and Cobb angle in the treatment group were significant differences from that of the control group (P＜005). The postoperative neurological function were improved significantly in the two groups(P＜005). The postoperative neurological function in the treatment group were significantly better than the control group (P＜005). The preoperative JOA scores was no significant difference between the two group (P＜005). The postoperative JOA score in the treatment group was significantly higher in that of the group (P＜005). Conclusion The short segment pedicle screw fixation for the nonadjacent multisegmental spinal fractures has more invasive security features, which can promote functions and lumbar functional recovery and help vertebral recovery.