【Abstract】 Objective To investigate the expression and clinical significance of lysyl oxidase (LOX) and extracellular matrix metalloproteinase inducer (CD147) in nonsmall cell lung cancer (NSCLC). Methods The expression of LOX and CD147 was measured by immunohistochemistry in 118 cases of NSCLC tissue, paracancerous tissue and paired normal lung tissues. Results LOX mainly expressed in the cytoplasm, CD147 in the cytoplasm and the cell membrane. The positive expression rate of LOX or CD147 in NSCLC tissues was significantly higher than those in paired normal tissues (P＜005). There was significant correlation between the expression of LOX or CD147 and tumor differentiation, tumor size, lymph node metastasis and TNM stage (P＜005). The LOX were positively correlated with the CD147 expression in NSCLC (rP=0578, P＜001). Conclusion The high expression of LOX and CD147 may play a pivotal role in the occurrence and development of NSCLC, and may act in synergy to promote the invasion and metastasis of NSCLC．