【Abstract】 Objective To study methylprednisolone and inhaled budesonide suspension liquid of elderly COPD acute exacerbation in patients with calcitonin and Creactive protein levels. Methods 86 COPD patients old than 60 years were randomly divided into observation group and control group with 43 cases in each group. The patients were treated with routine comprehensive treatment. The control group was treated with inhaled methyl prednisolone and the observation group with inhalation of budesonide suspension. The clinical efficacy, pulmonary function (FEV1, FEV1/FVC, MIP and MEP), blood gas indexes (PO2, pCO2), serum calcitonin), serum Creactive protein levels and adverse reactions wer observed.Results The total effective rate of observation group (93%) was significantly higher than that of control group. The indexes of pulmonary function and blood gas of the two groups were improved after treatment. Compared with that before treatment, PCT and CRP of the two group after treatment were significantly reduced (P＜005). In the control group, there were 1 patients with adverse reactions, and the group of patients after treatment was significantly elevated blood glucose (P＜005). Conclusion Inhalation of budesonide suspension can significantly improve lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD), have few side effects, regulate calcitonin generelated peptide and Creactive protein levels and improve the prognosis.