Objective To explore the curative effects of laparoscopic conservative surgery combined with Diphereline in the treatment of patients with ovarian endometriosis in child-bearing period and the effects on menstruation,pregnancy and recurrence.Methods 91 patients with ovarian endometriosis in child-bearing period treated in our hospital from January 2010 to August 2013 were divided into observation group(46cases)and control group(45cases).All the patients underwent laparoscopic conservative surgery.Based on this,1week after surgery,the observation group was treated with subcutaneous injection of diphereline,while the control group was treated with oral mifepristone tablets.The total effective rates of the treatment,postoperative recovery of menstruation,incidence rates of adverse drug reactions(including tidal fever and night sweating,acne,dizziness and fatigue,vaginal dryness,vaginal bleeding),the cumulative pregnancy rates and recurrence rates after 2-year followed-up were compared between the two groups.Results The total effective rate in the observation group[95.6%(44/46)]was higher than that in the control group [84.04%(35/45)]and the rate of menstruation recovering in 2months after drug withdrawal was significantly higher than that in the control group[64.4%(29/45)].The incidence rates of tidal fever and night sweating,acne in the observation group [15.2%(7/46),17.4%(8/46)]were higher than those in the control group [2.2%(1/45),4.4%(2/45)]and the 2-year cumulative pregnancy rate[67.4%(31/46)]was higher than that in the control group [44.4%(20/45)]while the recurrence rate[8.7%(4/46)]was lower than that in the control group [24.4%(11/45)](P<0.05).Conclusion The application of laparoscopic conservative surgery in ovarian endometriosis in child-bearing period can effectivelyremove ectopic lesions and the curative effect is good,which meets the fertility demand of women.The combination with Diphereline can further restrain growth of residual lesions,help postoperative recovery of menstruation and reduce the risk of recurrence after surgery.Although the incidence of adverse drug reactions is higher than that of mifepristone,the symptom is mild and patients can tolerate.Therefore,it is recommended to take laparoscopic conservative surgery combined with Diphereline as the preferred treatment regimen for ovarian endometriosis in child-bearing period. 更多