Objective To study the safety and efficacy of the continuous sufentanil infusion in elderly patients with gynecological surgery.Methods 80 60-85 years old elderly patients,ASA Ⅱ-Ⅲ,undergoing elective gynecological surgery,were randomly divided into group R(remifentanyl 6μg/kg/h)and group S(sufentanil 0.1μg/kg/h),40 cases in each group.After tracheal intubation,the patients maintained anesthesia with 1-3%sevoflurane,continuously infusion of sufentanil or remifentanyl respectively.10 minutes before the end of surgery,analgesics were stopped.The general condition,the vital signs,the dosage of ephedrine and atropine,the time to breathing recovery,the time to consciousness recovery,postoperative pain scores and the incidence of agitation at the moment of awareness recovery were recorded.Results,The incidence of hypotension and bradycardia in the group S was lower than that in the group R(37.5% vs60.5%,20% vs 62.5%,respectively,P<0.05).The dosage of ephedrine and atropine n the group S was also lower than that in the group R(5.48±2.27 vs12.4±3.23,0.33±0.12 vs 0.81 0.13,respectively,P<0.05).The time to breathing recovery and tidal volume recovery of the group R was shorter than that in the group S(4.3±2.2)min vs(6.3±3.4)min,(5.6±1.5)min vs(8.1±2.5)min,respectively,P<0.05).But the time to consciousness recovery was no statistical difference between two groups.Postoperative pain scores of the group R were obviously higher than that of the group S(6.5±2.6v.s.4.1±1.3,P<0.05).The incidence of agitation in the group S was lower than that in the groupR(12.5% v.s.55%,P<0.05).Conclusion Continuously infusing sufentanil can be safely used in elderly patients undergoing gynecological surgery.The advantages of it included remaining hemodynamic stability,improving postoprative recovery and analgesia,lessening adverse reactions.