艾司西酞普兰联合放松训练治疗焦虑障碍的效果评价
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四川省卫生厅科研课题(100346)


The effect of escitalopram citalopram combined with relaxation training on anxiety disorders
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    摘要:

    目的探讨艾司西酞普兰联合放松训练治疗焦虑障碍的疗效。方法采取随机数字法将110例焦虑障碍患者分成艾司西酞普兰联合放松训练治疗组(研究组)和单用艾司西酞普兰治疗组(对照组)各55例,治疗8周,于治疗前及治疗后第1、3、6、8周末采用汉密尔顿焦虑量表(HAMA)、焦虑自评量表(SAS)、临床疗效总评量表(CGI)评定疗效,用副反应量表(TESS)评定不良反应。结果治疗后第3、6、8周末两组HAMA、SAS、CGL评分与治疗前比较差异均有统计学意义(P<0.01或P<0.05);两组间HAMA、SAS、CGL评分在治疗后1、3、6、8周末比较差异亦有统计学意义(P<0.01或P<0.05);研究组TESS评分与治疗前比较差异有统计学意义(P<0.01),对照组差异无统计学意义(P>0.05),而两组TESS评分在治疗后比较差异亦有统计学意义(P<0.01);对照组发生不良反应14例(25.45%),研究组发生不良反应6例(10.9%),两组不良反应发生率比较差异亦有统计学意义(χ~2=3.911,P<0.05)。结论艾司西酞普兰联合放松训练治疗焦虑障碍的疗效优于单用艾司西酞普兰,临床疗效好,起效快,不良反应小,可在临床推广应用。

    Abstract:

    Objective To study the curative effect of escitalopram citalopram in combination with relaxation training on treatment of anxiety disorders.Methods 110 patients with anxiety disorder were divided into treatment group treated with escitalopram citalopram combination with relaxation training and control group treated with and escitalopram citalopram alone.Hamilton anxiety scale(HAMA),self-evaluation of anxiety scale(SAS),clinical efficacy evaluation curative effect and overall rating scale(CGI)with symptoms scale(TESS)were observed.Results HAMA,SAS and CGL score 3,6and 8weeks after treatment were statistically different from that before treatment(P<0.05).HAMA,SAS and CGL score 1,3,6and 8weeks after treatment of the two groups were different(P<0.01).TESS score of treatment group after treatment was different from that before treatment(P<0.01).TESS score after treatment of the two groups was significantly different.The incidence of adverse reaction of treatment group and control group were25.45% and 10.9%(χ~2=3.911,P<0.05).Conclusion Escitalopram citalopram with relaxation training can get good effect and few adverse reaction.

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  • 在线发布日期: 2016-12-02
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