Objective To observe the clinical effect of red laser combined with tamsulosin in the treatment of prostatic hyperplasia.Methods 76 patients with prostatic hyperplasia were selected as the research objects.According to the order of treatment,the patients were divided into the control group and the observation group,38 cases in each group.The control group was treated by routine transurethral resection of prostate(TURP)while the observation group was treated by red laser transurethral vaporization of the prostate.After surgery,the two groups were given tamsulosin intervention.The improvement of international prostate symptom scores(IPSS)in the two groups after surgery was compared.The differences in quality of life(QOL)scores before and after surgery were recorded.The post-void residual volume(PVR),maximum flow rate of urine(Qmax)and the incidence rates of postoperative complications in the two groups were statistically analyzed.Results The operation time of the observation group[(70.34±16.78)min]was longer than that of the control group[(56.44±17.58)min].The volume of intraoperative blood transfusion and the dosage of intraoperative irrigating liquid of the observation group[(25.36±4.78)ml,(45.32±14.21)ml)]were less than those of the control group[(19.84±4.33)ml,(96.48±23.69)ml)](P<0.05).The time of bladder washing,indwelling urinary catheter and the length of hospital stays of the observation group [(14.36±6.78)h,(4.56±1.39)d,(3.64±1.11)d]was shorter than that of the control group[(46.67±11.23)h,(5.97±0.26)d,(5.44±1.26)d](P<0.05).PVR in the two groups decreased significantly while Qmax increased significantly(P>0.05).3 month and 6 months after surgery,QOL and IPSS scores in the two groups were significantly improved(P<0.05).The incidence rate of postoperative complications in the observation group(10.53%)was significantly lower than that in the control group(31.58%)(P<0.05).Conclusion To adopt 980 nm semiconductor red laser vaporization combined with tamsulosin in the clinical treatment of patients with prostatic hyperplasia can reduce intraoperative blood loss,shorten hospitalization time,reduce the incidence of complications and improve the symptoms of prostate.