Objective To study effects of enteral nutrition of intraepithelial lymphocytes and mucus barrier function on the intestinal mucosa of patients with long-term fasting intestinal fistula.Methods The study was performed in60 patients with enterocutaneous fistula from April 2012 to December 2014 in our hospital.All patients were treated with enteral nutrition therapy.CD3~+,CD4~+,CD8~+ and iIEL levels,intestinal mucus barrier function in patients,and the implementation of nutrition indexes in patients with before and after EN were observed.Results CD3~+,CD4~+,CD8~+ and iIEL levels after 1 week and 2 weeks EN support were significantly higher than those before EN support(P<0.05).CD3~+,CD4~+,CD8~+ and iIEL levels 2 weeks after EN supports were significantly higher than 1 week after EN supports(P<0.05).The intestinal mucus thickness and mucin gene 2 2 weeks after EN supports were significantly higher than those before EN support and 1week after EN supports(P<0.05).The serum total protein,albumin and hemoglobin 1 week and 2 weeks after EN supports were significantly higher than those before EN support(P<0.05).Conclusion Enteral nutrition can improve immune function,which is good for long-term fasting patients with enterocutaneous fistula and mucus barrier. 更多