Objective To analyze the influence of sevoflurane inhalation anesthesia on circulation stability and serum proinflammatory factors in pregnant women undergoing elective cesarean section.Methods The clinical data of 98 puerperae who underwent cesarean section under general anesthesia were retrospectively analyzed. The patients were divided into sevoflurane group (n=52) and control group (n=46) according to whether sevoflurane inhalation anesthesia was selected. The maternal heart rate (HR)， systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared between the two groups before operation(T0)， at skin incision(T1)， at fetus delivery (T2) and after extubation (T3)， and the proinflammatory cytokines of interleukin-6(IL-6)， tumor necrosis factor-α(TNF-α) and soluble human tumor necrosis factor receptor Ⅱ(sTNFRⅡ) were measured before and after operation， and the changes of blood gas indexes and Apgar score were recorded in the two groups， and the maternal and neonatal outcomes were compared.Results Compared with at T0， the SBP and DBP in the two groups were decreased at T1~T2 (P<0.05)， and the SBP and DBP in sevoflurane group at T1~T2 were higher than those in control group (P<0.05).There were no significant differences in the blood gas indexes in cord blood and the Apgar scores at different neonatal delivery times between the two groups (P>0.05).Before operation， there were no significant differences in the levels of proinflammatory cytokines between the two groups(P>0.05).Immediately after operation， the levels of IL-6， TNF-α and sTNFR II in control group were higher than those in sevoflurane group (P<0.05).There were no statistically significant differences in the maternal-infant adverse events between the two groups (P>0.05).Conclusion Intraoperative sevoflurane maintenance has a smaller effect on hemodynamics of puerperae with cesarean section under general anesthesia， and has more obvious inhibition of cytokine release caused by stress， and it has no negative impact on the neonates， thus it is safe and feasible.