Objective To investigate the value of IVC-CI and NT-proBNP in fluid management of elderly patients with septic shock.Methods 103 patients with septic shock treated in the emergency department of Huangpu branch of the Ninth People′s Hospital Affiliated to the Medical College of Shanghai Jiaotong University from June 2020 to December 2021 were prospectively selected as the research objects. All the enrolled patients were treated as early as possible according to the 2018 International Sepsis cluster treatment guidelines, and the early curative effect was evaluated 6 hours later. Patients were divided into standard group and non-standard group according to whether they reached the recovery goal. The clinical data, severity score, rehydration volume, inferior vena cava related parameters, respiratory parameters and hemodynamic indexes of the two groups were compared. The diagnostic value of IVC-ci in reaching the standard of fluid resuscitation in elderly patients with septic shock was analyzed by ROC curve. Results The course of disease in the substandard group was significantly longer than that in the substandard group (P<0.05), but there was no significant difference between the two groups in the use time of vasoactive drugs and the type of rehydration (P>0.05). After treatment, the Apache Ⅱ score of patients in the standard group was significantly lower than that in the non-standard group, and the values of 24h fluid intake, 24h urine volume, minimum inspiratory end vena cava diameter (IVC min), maximum expiratory end vena cava diameter (IVC max), minimum diameter of inferior vena cava (IVCi), maximum diameter of inferior vena cava (IVCe) were significantly higher than those in the non-standard group. The heart rate was significantly lower than that in the non-standard group (P<0.05). The lactate clearance rate, mean arterial pressure (map) and central venous pressure (CVP) in the standard group were significantly higher than those in the non-standard group (P<0.05). The area of ROC curve for the diagnosis of fluid resuscitation in elderly septic shock patients by CVP was 0.804 (95% CI: 0.727-0.881, P<0.001), the critical value was 7.92 mmHg, the sensitivity was 72.36%, and the specificity was 69.47%. The ROC curve area of IVC-CI in diagnosis of elderly septic shock patients with fluid resuscitation reaching the standard was 0.873 (95% CI: 0.816-0.932, P<0.001), the critical value was 19.11%, the sensitivity was 79.17%, and the specificity was 70.83%. The ROC curve area of NT proBNP in diagnosing the elderly septic shock patients with fluid resuscitation reaching the standard was 0.889 (95% CI: 0.831-0.946, P<0.05), the critical value was 961.24 pg/ml, the sensitivity was 84.72%, and the specificity was 74.22%. The area of the ROC curve of CVP+IVC-CI+NT proBNP in the diagnosis of elderly septic shock patients with fluid resuscitation reaching the standard was 0.923 (95% CI: 0.877-0.094, P<0.05), the sensitivity was 87.52%, and the specificity was 76.39%. The ROC curve area of CVP+IVC-CI+NT proBNP was significantly higher than that of CVP, IVC-CI and NT proBNP alone (P<0.05). Conclusion After treatment, CVP, IVC-CI, NT-proBNP as a bedside, non-invasive examination means, are safe and effective. They can reflect the change of volume status before and after liquid therapy, help improve the patient′s respiratory parameters and hemodynamic indicators, and have good predictive effect and high sensitivity on the elderly septic shock patients′ fluid resuscitation