To explore the clinical efficacy of day surgery for lumbar disc herniation using spiral CT guided ozone injection and radiofrequency thermocoagulation. Methods The clinical data of 137 patients with lumbar disc herniation were collected retrospectively. Day surgery by using spiral CT guided ozone injection and radiofrequency thermocoagulation was applied for all patients. The surgery duration, mean length of hospital stay after surgery, and total hospital stay were recorded. Numerical rating Scale (NRS) and oswestry disability index (ODI), modified Macnab rating and postoperative complications one and three months later after the surgery were collected. The preoperative and postoperative data were statistically analyzed. Results The success rate of spiral CT guided puncture was 100% and all patients were discharged on the day of surgery. The mean surgery duration, mean length of hospital stay after surgery, and total hospital stay were (35.55±10.44)min, (58.36±25.26)min, and (453.91±27.18)min. The postoperative NRS and ODI were lower than preoperative NRS and ODI. The standard effective rates of modified Macnab one and three months after the day surgery were 86.13% and 89.05%. No postoperative complications were found. Conclusion The day surgery for lumbar disc herniation using spiral CT guided ozone injection and radiofrequency thermocoagulation is feasible, which is worth of popularization considering its advantages including reducing the patients' pain degree, improve their daily dysfunction, and high safety