To explore the application of joint mobilization in the treatment of distal radius fracture healing and wrist function recovery, and analyze its influencing factors and related predictive factors. Methods The clinical data of 256 patients with distal radius fractures who underwent joint mobilization from May 2018 to December 2021 were analyzed, retrospectively. According to the fracture healing and joint function recovery, the patients were divided into good effect group (214 cases) and poor effect group (42 cases). The fracture healing of the two groups were compared, such as fracture healing time, primary healing and secondary healing; Wrist function score (Gartland werley) was used to evaluate and compare the recovery of wrist function between the two groups. The factors that may affect the clinical effect of joint loosening surgery, such as gender, age, tendon skin injury, osteoporosis and fracture AO classification, were analyzed by multivariate analysis, and then the risk factors affecting the clinical effect of joint loosening surgery were analyzed by binary logistic regression. ROC curve analysis of clinical indicators to predict the effect of joint mobilization. Results The fracture healing time and hospital stay in the good effect group were significantly lower than those in the poor effect group (P＜0.05). After treatment, the joint range of motion in the good effect group was better than that in the poor effect group (P＜0.05), and the ulnar deviation angle and palmar inclination angle were significantly greater than those in the poor effect group (P＜0.05). The excellent and good rate of wrist function recovery in the good effect group was 86.91%, which was significantly higher than 50% in the poor effect group (P＜0.05). Multivariate analysis and binary logistic regression analysis showed that age ＞60 years old, gender female, combined with osteoporosis, combined with other ipsilateral fractures, combined with tendon and ligament injury, and type B/C in AO classification of fractures were all risk factors affecting the clinical effect of joint loosening. Age, sex, osteoporosis, other fractures on the affected side, and AO classification of fractures predicted the area under the efficacy curve (AUG) of loosening surgery was 0.868, 0.846, 0.807, 0.809, 0.735. Conclusion The treatment of postoperative patients with distal radius fracture with joint mobilization is conducive to the healing of distal radius fracture and can accelerate the recovery of wrist function. Among them, age greater than 60 years old, female, combined with osteoporosis, combined with other ipsilateral fractures, combined with tendon and ligament injury, and type b/c in fracture AO classification are all risk factors affecting fracture healing and joint function recovery, which have a certain clinical value in predicting the effect of joint loosening surgery