To compare the clinical efficacy and cost of bone bridge post and interference screw in the reconstruction of anterior cruciate ligament of knee. Methods 700 cases of anterior cruciate ligament reconstruction under arthroscopy were retrospectively studied. The femoral tunnel was fixed by cross nail. The patients were divided into bone bridge post group (380 cases) and interference screw group (320 cases) according to the fixation method of tibial end of graft. The operation time, incision length, hospital stay and cost were compared between the two groups, and the intraoperative conditions were evaluated. The size of tibial tunnel, Lyshlom score of knee function and joint laxity at 3 and 12 months after operation were compared between the two groups.Results There were no significant differences in operation time, tibial incision length and hospital stay between the two groups (P＞0.05), but the operation cost of bone bridge post group was significantly lower than that of interference screw group (P＜0.05). There were no significant differences in tibial tunnel size, Lyshlom score and joint laxity between the two groups at 3 and 12 months after operation (P＞0.05), but with the extension of time, the two groups had different degrees of enlargement of the tunnel (P＜0.05). Conclusion For arthroscopic anterior cruciate ligament reconstruction, tibial fixation with bone bridge post can achieve the same clinical effect as interference screw fixation, but it has more medical and economic advantages. It is a kind of tibial fixation method worthy of widespread promotion