To evaluate the clinical efficacy of full endoscopic lamina fenestration discectomy (Endo-LOVE) by using visual trephine in the treatment of degenerative lumbar spinal stenosis.Methods From September 2019 to September 2020, 69 cases with degenerative lumbar spinal stenosis accepted Endo-LOVE by using visual trephine. The operation time, blood loss during operation, times of intraoperative radiation and the complications were recorded. The leg and low back pain Visual analogue score (VAS), Oswestry disability index (ODI) and modified MacNab were assessed preoperation, 1d, 3 months postoperation and at the follow-ups. The technical advantages of visual trephine in Endo-LOVE were summarized.Results All of the 69 operations were completed successfully with operational time 45～90(66.9±12.4)min, blood loss during operation 5～30(10.7±6.1)mL, 2～7(3.1±1.2)times of intraoperative radiation, 5～8(6.4±1.0)days of hospitalization time.1patient occurred cerebrospinal fluid leakage in postoperation. There were not other complications, such as nerve root injury or infection. All the patients were followed up for 3～8(6.1±1.5)months. The ODI, the low back pain and leg VAS in the 1day, 3months, last follow-up of postoperation were all improved compared with preoperation. The differences were statistic significantly(P＜0.05).The clinical efficacy was evaluated at the last follow-up by modified MacNab therapeutic effect evaluation criterion, excellent in 62 cases, good in 4cases, fair in 3 cases. The excellent and good rate was 95.65%.Conclusion The application of visual trephine in Endo-LOVE technology helps to shorten the operation time, wide decompression range, visual operation, high safety and satisfactory clinical efficacy, which is worthy of promotion