To explore the effect of conventional western medicine, Yiwei Huoxue Decoction combined with Diling Weitong Granules on HP associated gastritis.Methods A total of 200 patients with HP-related gastritis of Qi-stagnation and blood-stasis type diagnosed and treated by the Department of Gastroenterology in Langfang People's Hospital from June 2021 to December 2022 were gathered.They were divided into combination group, traditional Chinese medicine decoction group, traditional Chinese medicine granule group, and western medicine group using random number table method, with 50 patients in each group.The western medicine group was treated with conventional clinical western medicine, the Chinese medicine granule group was treated with cubeb granule on the basis of western medicine group, the Chinese medicine decoction group was treated with traditional Yiwei Huoxue decoction on the basis of western medicine group, and the combined group was treated with cubeb granule and traditional Yiwei Huoxue decoction on the basis of western medicine group.The symptom relief time, clinical efficacy, gastric mucosal lesion score under gastroscopy, T lymphocyte subgroup level, HP eradication rate and medication safety were compared among the four groups.Results Compared with western medicine group, combined group had higher efficacy and HP eradication rate, and fewer adverse drug reactions (P＜0.05).Compared with the western medicine group, the Chinese medicine granule group, the Chinese medicine decoction group, the combined group had shorter symptom relief time, and the Chinese medicine granule group, the Chinese medicine decoction group was shorter than the Western medicine group(P＜0.05).After treatment, the levels of CD3, CD4 and CD4/CD8 in the four groups increased and CD8 decreased compared with those before treatment.The levels of CD3, CD4 and CD4/CD8 in the combined group after treatment were higher than those in the other three groups, and the scores of gastric mucosal lesions and CD8 levels under gastroscopy were lower than those in the other three groups (P＜0.05).Conclusion The effect of conventional western medicine, Yiwei Huoxue Decoction combined with Diling Weitong Granules in the treatment of Hp-related gastritis of Qi stagnation and blood stasis is superior to the single application of three drugs, including that the symptom remission time of patients is significantly shortened, the eradication rate of HP is significantly increased, the immune function of patients is effectively improved, and the drug safety is high