This study explored the relationship between resting heart rate and elevated blood pressure in adolescents of different genders, providing a scientific basis for the prevention and control of hypertension in adolescents. Methods From January 1 to December 31, 2018, we collected the information on physical examinations of 2688 adolescents aged 11 to 18 years from The Second People's Hospital of Zhaotong. The information included age, gender, height, weight, resting heart rate, systolic blood pressure, and diastolic blood pressure. In this study, Univariate analysis and binary logistic regression model were performed to analyze the correlation between resting heart rate and elevated blood pressure.Results Among 2688 subjects, 1375 (51.15%) were males and 1313 (48.85%) were females, the gender ratio was 1.04∶1 (male: female). The prevalence of high blood pressure was 26.0%, including 26.6% in boys and 25.4% in girls. Logistic regression showed that increased resting heart rate and BMI are the risk factors for higher blood pressure in investigated population. After adjusting for the effects of BMI, each 10bpm aggrandize in resting heart rate was associated with an increased risk of hypertension of 33.8%(OR=1.338，95%CI=1.247~1.437), 30.2%(OR=1.302，95%CI=1.179~1.437) in male and 43.3% (OR=1.433，95%CI=1.289~1.593) in female. Conclusion Elevated resting heart rate and increased BMI are hazards for high blood pressure of 11-18-year-old teenagers in this region. The resting heart rate is positively correlated with the possibility of high blood pressure. As the BMI rises, the risk of high blood pressure increases. Health promotion and early screening of hypertension were supposed to implement to alleviate the economic and social burden due to cardiovascular diseases among adolescents in this region