To explore the optimal detection method for COVID-19 by comparing different combinations of fast and common nucleic acid detection system. Methods COVID-19 nucleic acid liquid quality control reference was diluted to the concentration of 200 cp/mL, 500 cp/mL, 1000 cp/mL and 2000 cp/mL. The common detection system (nucleic acid extraction method, common amplification reagent and common RT PCR instrument) and rapid detection system (direct pyrolysis release method, rapid amplification reagent and rapid RT PCR instrument) were used. The units of common and rapid detection system were mixed and matched to explore the best detection system. Results Using the common detection system, the time was the slowest (134 min), but the sensitivity was the best. Using the rapid detection system, the time was the fastest (56 min), but the sensitivity was worst. The reason for the poor sensitivity may be attributed to the direct pyrolysis release method. Further research found that the common nucleic acid extraction, the rapid amplification reagent and rapid RT PCR instrument were the best combined application in COVID-19 nucleic detection. The combination of the detection time was fast (59 min), and the sensitivity was better. Conclusion It is not recommended to use the direct lysis-release method to extract nucleic acid. However, the efficiency and time can be improved by using rapid amplification reagent and rapid RT PCR instrument