To discuss the optimization of one-stop pancreatic CT perfusion scanning time based on multiple diagnostic tasks.Methods A retrospective analysis was conducted on 72 cases of normal pancreatic perfusion using the third generation dual source CT in Deyang People's Hospital from July 2018 to November 2020. They were divided into group A and group B according to different scanning parameter settings. Group A (routine perfusion group, 24 cases):intensive collection time was 1.5 s, 24 dynamic volume scans, total collection time was 94.5 s. Group B (time optimization group, 48 cases): intensive collection time 2.5 s, 19 dynamic volume scans, total collection time 75 s. Three modes of CT diagnostic data were reconstructed according to perfusion data set to evaluate the satisfaction of diagnostic requirements. Signal to noise ratio (SNR) and contrast to noise ratio (CNR) of corresponding phase images of aorta, pancreas and portal vein were evaluated based on conventional enhanced images. Evaluate the degree of peripancreatic vascular variation based on routine angiogram. The perfusion parameters of pancreatic uncinate process, head, body and tail were compared, including blood flow (BF), blood volume (BV), mean transit time (MTT) and surface permeability (PS). Record the effective radiation dose.Results The difference in objective indexes of multi-phase images between A and B group did not had statistical significance (P＞0.05). Left gastric artery directly started with celiac axis in 8 cases (A group 3/24, B group 5/48), right hepatic artery directly started with superior mesenterie artery in 2cases (A group 1/24, B group 1/48), left hepatic artery directly started with celiac axis in 3 cases (B group 3/48). All image quality could satisfy the assessment of vascular variations. The difference in perfusion data between A and B group did not achieve statistical significance (P＞0.05). With 2.5 sintensive sampling intervalin group A, ED could be reduced by approximately 22.8%.Conclusion Compared with the 1.5 sintensive sampling interval,using 2.5 sintensive sampling intervalin upper abdomendynamic volume perfusion CT,ED could be reduced without compromising the fulfillments in multiple diagnostic tasks