To explore the effects of dexmedetomidine before induction of anesthesia on awakening time, analgesic effect and hemodynamics in patients undergoing scoliosis correction surgery. Methods 113 patients who underwent scoliosis correction surgery in the hospital from January 2021 to December 2021 were selected as the research subjects, and they were divided into the observation group and the control group according to the simple randomization method. The observation group (n=57) was injected intravenously with 0.8 μg/kg dexmedetomidine within 10 min before anesthesia induction, and the control group (n=56) was injected with the same amount of normal saline during the same time period, and the patients in the two groups were subjected to general anesthesia. The hemodynamic indicators of heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SpO2)］ before anesthesia intubation (T0), at 10 min after intubation (T1), at 10 min before awakening (T2), during awakening (T3), at 5 min after awakening (T4) and at 10 min after deepening anesthesia, postoperative awakening time, awakening quality, incidence rate of agitation during awakening, analgesic effect ［Visual Analogue Scale (VAS)］ immediately after extubation and at 2 h, 6 h and 24 h after surgery, stress response ［serum cortisol (Cor), aldosterone (ALD), blood glucose (Glu)］ before anesthesia and at 2 h and 6 h after surgery and drug safety were compared between the two groups.Results There were statistical differences in group effect, time-point effect and interaction effect of between-group×time-point of HR and MAP (P＜0.05), and the differences in HR and MAP at T3 and T4 in observation group were statistically significant (P＜0.05). There were no statistical differences in the between-group effect, time-point effect and interaction effect of betweengroup×time-point of SpO2 (P＞0.05). The quality of awakening in observation group was significantly higher than that in control group (P＜0.05), and the incidence rate of agitation during awakening was significantly lower than that in control group (P＜0.05), and there was no statistical difference in the awakening time between the two groups (P＞0.05). The differences in between-group effect, time-point effect and interaction effect of between-group×time-point of VAS score were statistically significant (P＜0.05), and the difference at each time period within the groups was statistically significant (P＜0.05), and the VAS score in observation group was significantly lower than that in control group at 2 h and 6 h after surgery (P＜0.05). The between-group effect, time-point effect and interaction effect of levels of peripheral blood Cor, ALD and Glu were statistically different (P＜0.05), and the levels at each time period within the groups were increased in turn (P＜0.05), and the levels of Cor, ALD and Glu in peripheral blood in observation group at 2 h and 6 h after surgery were significantly higher than those in control group (P＜0.05). The rate of adverse reaction was 5.26% in observation group and 8.93% in control group (2=0.154, P=0.694). Conclusion Dexmedetomidine before anesthesia induction in scoliosis correction surgery is beneficial to improving the intraoperative awakening quality, reducing the intraoperative hemodynamic fluctuations and improving the postoperative pain and stress response, with good application value