To evaluate the pregnancy outcomes of the advanced age patients with diminished ovarian reserve who received in vitro fertilization and embryo transfer (IVF-ET) cycle treatment with different ovulation induction programs.Methods The clinical data of 377 cycles of elderly patients with low ovarian reserve who received IVF in the reproductive medicine center of our hospital were collected. There were 198cycles of ovulation induction regimen (PPOS group), 103cycles of long regimen (long regimen) and 76 cycles of antagonist regimen (antagonist group). The clinical indexes of different ovulation induction schemes were evaluated comprehensively.Results The total amount and days of gonadotropin (Gn) used in the long regimen group were the highest, and the LH level on HCG day was the lowest. The maturation of M Ⅱ follicles, the number of 2PN fertilized and the number of excellent embryos were higher than those of the other two groups (P＜0.001). The egg acquisition rate of PPOS group was the highest, followed by long regimen group, which was higher than that of antagonist group (P＜0.001), the normal fertilization antagonism group was the highest, followed by long regimen group, which was higher than that of PPOS group (P＜0.001).In the comparison of pregnancy outcome, the fresh embryo transfer rate of long regimen group was higher than that of antagonist group, and the elimination rate of fresh embryo transfer of antagonist group was higher than that of long regimen group, but there was no significant difference (P＞0.001). The cumulative embryo implantation rate of long regimen group was higher than that of antagonist group and PPOS group, and there was significant difference between long regimen group and PPOS group (P＜0.001).The cumulative clinical pregnancy rate and cumulative live birth rate in the GnRH-a long protocol group were higher than those in the GnRH-ant protocol group and PPOS group, but there was no significant difference among the three groups(P＞0.05). There was no significant difference in abortion rate among the three groups(P＞0.05).Conclusion The patients with diminished ovarian reserve in advanced age can also choose GnRH-a long protocol should have better outcome for pregnancy in vitro fertilization and embryo transfer