To investigate the correlation and predictive value of dp-ucMGP and BGP levels with type 2 diabetic kidney disease (DKD), and provide a new conception for the diagnosis of DKD. Methods A total of 138 patients with type 2 diabetes mellitus were collected from December 2020 to October 2021 who were admitted to the endocrinology department of our hospital. According to the urinary microalbumin/creatinine (ACR) level. The patients with ACR＜3mg/mmol were divided into plain diabetes group (DM, n=56), ACR between 330 mg/mmol was in the early diabetic kidney disease group (eDKD, n=38), ACR＞30mg/mmol was classified as clinical diabetic kidney disease group (cDKD, n=44). dp-ucMGP, BGP levels and other clinical biochemical indexes were inspected. Results In contrast to DM group, dp-ucMGP in eDKD group and cDKD group was increased, while BGP was decreased (P＜0.05). Spearman correlation analysis showed that dp-ucMGP was positively correlated with ACR, CRE, UREA levels, and negatively correlated with eGFR. BGP was negatively correlated with ACR. Logistic regression demonstrated that dp-ucMGP was a risk factor for DKD, and BGP was a protective factor. The sensitivity of the combined diagnosis of DKD was 0.781, the specificity 0.750, and the AUC was 0.838 (95% CI:0.773-0.902) as determined by ROC curve analysis. Conclusion Dp-ucMGP is a risk factor of DKD, BGP is a protective factor of DKD, both of them have certain value for the diagnosis of DKD