Androgen plays an important role in maintaining the normal structure and function of penile corpus cavernosum. More and more patients need to keep low androgen status with the increasing incidence of prostate cancer. In low androgen status, nutritional function of androgen on the smooth muscle of penile corpus cavernosum impaired, and the number and relaxation of smooth muscle cells decreased, which result in reduced blood flow in penis and lead to erectile dysfunction (ED). Understanding the molecular mechanism of ED induced by low androgen status is key to improve erectile function in patients requiring maintenance of low androgen status