《高甘油三酯血症性急性胰腺炎诊治急诊专家共识》解读
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四川省科技厅项目(20-4-566);四川省科技厅科技培训(2022JDKP0030)


Interpretation of emergency expert consensus on diagnosis and treatment of hypertriglyceridemic acute pancreatitis
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    摘要:

    高甘油三酯血症是急性胰腺炎的一种常见且诊断不足的病因。游离脂肪酸脂毒、微循环障碍、氧化应激、钙超载、遗传等机制参与了高甘油三酯血症性急性胰腺炎(HTG-AP)发病,临床上呈现年轻化、重症化的趋势,早期规范化诊疗是其治疗关键。2021年,来自全国的急重症专家采用共识会议就HTG-AP病因、发病机制、临床特征、严重程度分级、病因治疗、常规治疗等方面进行了系统性阐释,形成《高甘油三酯血症性急性胰腺炎诊治急诊专家共识》。该共识内容既与国际上重要指南和共识保持一致,同时也具有鲜明的高脂血症特色理念、方式和策略,是国内外第一部关于高甘油三酯血症性胰腺炎急诊诊治的专家共识。目前,该共识对我国HTG-AP诊疗起到了积极的促进作用;但临床医师特别是急诊医师对如何早期控制血清TG水平和阻止全身炎症反应综合征( SIRS),仍然有诸多疑惑。为此,本文就共识中HTG-AP病因与发病机制、诊断、降脂治疗等三大部分内容共计15个具体临床问题,结合新的HTG-AP临床诊治循证医学证据,进行以下解读。

    Abstract:

    Hypertriglyceridemia (HTG) is a well established but often missdiagnosed cause of acute pancreatitis. The mechanism responsible for HTG-AP is related to free fatty acid (FFA) lipotoxicity, microcirculatory disorder, oxidative stress, Ca2+ overload, and genetic polymorphism. HTG-AP is often associated with greater clinical severity and rate of complications. Therefore, accurate diagnosis of HTG-AP as soon as possible is essential so that patients receive the appropriate treatment. In 2021, based on consensus development conference, experts on emergency medicine from all over the country had built consensus on definition, etiology, pathogenesis, clinical features, severity classification, etiology treatment, routine treatment and other aspects of HTG-AP, and formed the highly operable “Emergency Management of Hypertriglyceridemia Acute Pancreatitis: a consensus statement”. The content of this consensus was not only accords with the important international guidelines and consensus, but also had distinct characteristics of hyperlipidemia concept, methods and strategies. It was the first global expert consensus on the diagnosis and treatment of hypertriglyceridemia pancreatitis. The consensus has been released for one year, which has played a positive role in promoting the accurate and efficient diagnosis and management of HTG-AP in China. However, clinicians, especially emergency physicians, still have many questions about how to control serum TG level and prevent the occurrence of systemic inflammatory response syndrome in emergency department. This present review aims to interpret the reported 15 recommendation of this consensus by reviewing the recent literature on the topic of HTG-AP.

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  • 在线发布日期: 2022-12-21
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