Spondyloarthritis (SpA), represented by ankylosing spondylitis, often occurs in young adults and causesdisability in severe cases. It is an important cause of disability in young adults in China. Because of its insidious onset, it is not easily identified in the early stage with high rate of misdiagnosis. This article provides an in-depth dissection of the clinical manifestations, causes, and resolution of SpA with mental disorders .With the change of diagnosis concept and the publication and implementation of new classification standard, the rate of misdiagnosis and mistreatment of SpA has been showing an increasing tendency, and the resulting series of "adverse reactions" should be of high concern rheumatologists. Herein, we call on specialists to be fully aware of the severity of SpA mental disorders and pay high attention psychological rehabilitation as an integral part of its treatment.