【Abstract】 Objective To analyze the intervention effect and mechanism of simvastatin on cerebral ischemia-reperfusion injury model rats. MethodsA total of 40 healthy male rats with SPF grade SD were selected，10 were in the normal group，and 40 were established to model cerebral ischemia in perfusion injury and underwent separate interventions. The neurological functions and learning and memory abilities of the rats were evaluated，and the levels of inflammatory factors and stress response indicators were detected to analyze the efficacy of the interventions and the underlying mechanisms. ResultsCompared with the normal group，the model group had lower learning and memory ability and higher neurological impairment score；Compared with model group and low-dose group，high-dose group had higher learning and memory ability and lower neurological impairment score (P<0.05). Compared with normal group，the levels of IL-1β，TNF-α，hs-CRP and MDA in model group were increased，while the levels of GSH-Px and SOD were decreased (P<0.05). Compared with model group and low-dose group，the levels of IL-1β，TNF-α，hs-CRP and MDA in high-dose group were lower，and the levels of GSH-Px and SOD were higher (P<0.05). ConclusionSimvastatin can reduce cerebral ischemia-reperfusion injury and improve cognitive impairment caused by ischemia. It has a good protective effect on cerebral ischemia-reperfusion，which may be related to reducing inflammation and antiaperoxidation injury.