Objective To investigate the therapeutic effect of resveratrol on Pseudomonas aeruginosa pneumonia immunosuppressive mice based on SIRT1/ROR-γt pathway. Methods The mice were randomly divided into blank group, Pseudomonas aeruginosa pneumonia (PA) group, immunosuppression group, immunosuppression+PA group and immunosuppression+PA+resveratrol group, with 18 mice in each group. The mice in each group were killed at 4, 8 and 24 hours after successful modeling. The hematoxylin eosin (HE) staining was used to observe the pathological changes of lung tissue in mice. The lung histopathological score was performed. The expression level of IL-17 was detected by enzyme linked immunosorbent assay (ELISA). The mRNA expression levels of SIRT1 and ROR-γt in lung tissue were detected by real-time fluorescence quantitative PCR. The protein levels of SIRT1 and ROR-γt were detected by Western blot.Results Compared with the blank group, the alveolar structure of PA group, immunosuppressive group and immunosuppressive + PA group was seriously damaged, and a large number of neutrophils and inflammatory cells were observed in the alveoli. The histopathological score, the content of IL 17 and ROR γ The expression levels of T mRNA and protein increased significantly (P＜0.05), and the expression levels of SIRT1 mRNA and protein decreased significantly (P＜0.05). Compared with immunosuppression + PA group, the pathological symptoms, inflammatory cell infiltration, lung histopathological score, IL 17 content and ror in immunosuppression+PA+resveratrol group were reduced.The expression levels of γT mRNA and protein decreased significantly (all P＜0.05), and the expression levels of SIRT1 mRNA and protein increased significantly (all P < 0.05). Conclusion Resveratrol may inhibit inflammatory reaction and alleviate lung tissue injury in immunosuppressive pneumonia mice induced by Pseudomonas aeruginosa by up-regulating SIRT1 expression and down-regulating ROR-γt expression.